Byne integrates ByOnic's peptide identifications into a list of proteins, ranked by confidence (p-value). The combination of ByOnic and ComByne greatly outperforms current standards, such as Mascot and ProteinProphet. ByOnic typically identifies 50 to 100 percent more spectra. On complex samples with many low-abundance proteins, ComByne then identifies 30 to 50 percent more proteins.