Nature Reviews Microbiology 13, 398 (2015)
Antimicrobials: Fine-tuned antifungals
Naomi Attar.
Resistance to the antifungal drug Amphotericin B (AmB) has not evolved but it is extremely toxic to humans. AmB extracts the fungal sterol ergosterol from fungal membranes and its toxicity probably results from cross-reactivity with human cholesterol. Davis et al. designed a new class