Nature Reviews Molecular Cell Biology 16, 443 (2015)
Discovering centromere proteins: from cold white hands to the A, B, C of CENPs
William C. Earnshaw.
The kinetochore is a complex molecular machine that directs chromosome segregation during mitosis. It is one of the most elaborate subcellular protein structures in eukaryotes, comprising more than 100 different proteins. Inner kinetochore proteins associate with specialized centromeric chromatin containing the histone H3 variant centromere