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PNAS

Empirical inference of circuitry and plasticity in a kinase signaling network [Biochemistry]

E. H. Wilkes, C. Terfve, J. G. Gribben, J. Saez-Rodriguez, P. R. Cutillas.
Our understanding of physiology and disease is hampered by the difficulty of measuring the circuitry and plasticity of signaling networks that regulate cell biology, and how these relate to phenotypes. Here, using mass spectrometry-based phosphoproteomics, we systematically characterized the topology of a network comprising the PI3K/Akt/mTOR and MEK/ERK signaling axes...