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PNAS
Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly [Biochemistry]
A. P. AhYoung, J. Jiang, J. Zhang, X. Khoi Dang, J. A. Loo, Z. H. Zhou, P. F. Egea.
Membrane contact sites (MCS) between organelles are proposed as nexuses for the exchange of lipids, small molecules, and other signals crucial to cellular function and homeostasis. Various protein complexes, such as the endoplasmic reticulum-mitochondrial encounter structure (ERMES), function as dynamic molecular tethers between organelles. Here, we report the reconstitution and...