熱點文獻
PNAS
Regulation by a chaperone improves substrate selectivity during cotranslational protein targeting [Biochemistry]
A. Ariosa, J. H. Lee, S. Wang, I. Saraogi, S.-o. Shan.
The ribosome exit site is a crowded environment where numerous factors contact nascent polypeptides to influence their folding, localization, and quality control. Timely and accurate selection of nascent polypeptides into the correct pathway is essential for proper protein biogenesis. To understand how this is accomplished, we probe the mechanism by...