熱點文獻
PNAS
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy [Cell Biology]
A. Ordureau, J.-M. Heo, D. M. Duda, J. A. Paulo, J. L. Olszewski, D. Yanishevski, J. Rinehart, B. A. Schulman, J. W. Harper.
The PTEN-induced putative kinase protein 1 (PINK1) and ubiquitin (UB) ligase PARKIN direct damaged mitochondria for mitophagy. PINK1 promotes PARKIN recruitment to the mitochondrial outer membrane (MOM) for ubiquitylation of MOM proteins with canonical and noncanonical UB chains. PINK1 phosphorylates both Ser65 (S65) in the UB-like domain of PARKIN and...