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PNAS

Laying a controversial smell theory to rest [Biophysics and Computational Biology]

L. B. Vosshall.
In the 50 y before the cloning of the odorant receptors (ORs) by Linda Buck and Richard Axel in 1991 (1), two competing mechanisms for odor detection were discussed, one chemical and one spectral. The chemical theory posited that “detectors” respond to physicochemical attributes of the odorant, including molecular size,...